The new Spider-Man film has begun casting, with Andrew Garfield as Spider-Man (presumably a Spider-Man who hates Mondays and loves to eat his own weight in lasagna. It's a daring choice.) They're also working on casting his love interest, an as-yet-unnamed character (or, at least, one whose name they're not putting on the scripts that are circulating through Hollywood) who apparently is definitely probably not Mary Jane Watson.
Since I'm bored, I'm going to go ahead and circulate a half-baked conspiracy theory that I may or may not believe. Remember how "One More Day" happened, and went over like a lead balloon stuffed with dwarf star material because contrary to editor-in-chief Joe Quesada's expectations, nobody really was pining for a Spider-Man comic that looked just like the ones that came out when he was a kid in 1970? And how to the average Spider-Man fan, Mary Jane was and pretty much always had been Spidey's "true love", because we didn't even start reading comics until almost after they were married? And how the casual fan had barely even heard of Gwen Stacy, because all the film adaptations, cartoon versions, and even most of the non-616 versions of Spider-Man had Peter dating MJ?
So now they're rebooting the movies with a new, MJ-free version. The "Spider-Man Loves Mary Jane" comic got canceled a while back, despite great reviews and steady trade paperback sales. Ultimate Spider-Man is living with Gwen Stacy. There hasn't been a cartoon Spidey in a little while, but the last one had a far more prominent role for Gwen and emphasized MJ's desire to stay single. (Yes, I know, they're returning to the original series' roots. That is rather my point, though.) All in all, it seems like there's a concerted branding effort to take MJ out of the picture in order to bring the alternate media versions of Spider-Man in line with the "Amazing" version, complete with what seems like a plan to push Gwen Stacy to the forefront.
Does this mean that Joe Quesada is abusing his lofty position within Marvel's hallowed halls in order to make all comics just like they were when he was a kid? (If so, he could probably take some lessons from Geoff Johns. **rimshot**) I doubt it, really. It seems like a lot of work for such a petty agenda. But if the new movie girlfriend for Spidey is named "Gwen Stacy", well...all I'm saying is, don't be surprised if there's a "shocking resurrection" a few years down the line in the main Spidey book.